01 - Pat shrimp completely dry with paper towels. Season both sides with kosher salt and black pepper, ensuring even coverage.
02 - Arrange three shallow bowls. In the first, whisk together flour, cornstarch, garlic powder, and smoked paprika. Place beaten eggs in the second bowl. Add panko breadcrumbs to the third bowl.
03 - Dredge each shrimp in the flour mixture, shaking off excess. Dip into beaten eggs, allowing excess to drip off. Press firmly into panko breadcrumbs, coating completely and shaking off loose crumbs.
04 - Pour 2 inches of vegetable oil into a deep skillet or Dutch oven. Heat to 350°F, maintaining temperature throughout frying.
05 - Fry shrimp in batches, avoiding overcrowding. Cook for 2 to 3 minutes, turning halfway through, until golden brown and crispy. Remove with tongs and drain on paper towel-lined plate.
06 - Combine honey, hot sauce, butter, and red pepper flakes in a small saucepan over low heat. Stir constantly until butter melts and mixture is heated through, about 2 minutes. Do not boil.
07 - Transfer fried shrimp to a large bowl. Pour hot honey glaze over shrimp and toss gently until evenly coated. Serve immediately, garnished with fresh chives or parsley and lemon wedges on the side.